Comparing Evolutionary Operators, Search Spaces, and Evolutionary Algorithms in the Construction of Facial Composites

Facial composite construction is one of the most successful applications of interactive evolutionary computation. In spite of this, previous work in the area of composite construction has not investigated the algorithm design options in detail. We address this issue with four experiments. In the first experiment a sorting task is used to identify the 12 most salient dimensions of a 30-dimensional search space. In the second experiment the performances of two mutation and two recombination operators for interactive genetic algorithms are compared. In the third experiment three search spaces are compared: a 30-dimensional search space, a mathematically reduced 12-dimensional search space, and a 12-dimensional search space formed from the 12 most salient dimensions. Finally, we compare the performances of an interactive genetic algorithm to interactive differential evolution. Our results show that the facial composite construction process is remarkably robust to the choice of evolutionary operator(s), the dimensionality of the search space, and the choice of interactive evolutionary algorithm. We attribute this to the imprecise nature of human face perception and differences between the participants in how they interact with the algorithms. Povzetek: Kompozitna gradnja obrazov je ena izmed najbolj uspešnih aplikacij interaktivnega evolucijskega ra?cunanja. Kljub temu pa do zdaj na podro?cju kompozitne gradnje niso bile podrobno raziskane možnosti snovanja algoritma. To vprašanje smo obravnavali s štirimi poskusi. V prvem je uporabljeno sortiranje za identifikacijo 12 najbolj izstopajo?cih dimenzij 30-dimenzionalnega preiskovalnega prostora. V drugem primerjamo u?cinkovitost dveh mutacij in dveh rekombinacijskih operaterjev za interaktivni genetski algoritem. V tretjem primerjamo tri preiskovalne prostore: 30-dimenzionalni, matemati?cno reducirani 12-dimenzionalni in 12-dimenzionalni prostor sestavljen iz 12 najpomembnejših dimenzij. Na koncu smo primerjali uspešnost interaktivnega genetskega algoritma z interaktivno diferencialno evolucijo. Rezultati kažejo, da je proces kompozitne gradnje obrazov izredno robusten glede na izbiro evolucijskega operatorja(-ev), dimenzionalnost preiskovalnega prostora in izbiro interaktivnega evolucijskega algoritma. To pripisujemo nenatan?cni naravi percepcije in razlikam med interakcijami uporabnikov z algoritmom

The regulation of DCDC2, a candidate gene for dyslexia

Within the human genome, genetic mapping studies have identified ten regions of different chromosomes, known as DYX loci, in genetic linkage with dyslexia. The gene DCDC2, located within the DYX2 region on chromosome 6p22, has been shown to have genetic association with dyslexia in several independent studies. Functional assays of DCDC2 indicate that it may help guide the migration of neurons during early brain development. DCDC2 polymorphisms that display the strongest association with dyslexia are located in a highly GC-rich region in intron 2 known as BV677278. These polymorphisms contain several transcription factor binding sites, including the canonical 8-base recognition site for PEA3, a transcription factor known to modulate neuronal migration in mice. We hypothesized that 1) BV677278 is an enhancer element for DCDC2 that regulates its expression level, location, or timing, and that 2) PEA3 regulates DCDC2 expression by binding BV677278. To test these hypotheses we showed that PEA3 binds to regions within BV677278, and that siRNA knockdown of PEA3 appears to delay the expression of DCDC2 during neuronal differentiation of mouse cells. We concluded that PEA3 was a viable candidate transcription factor for DCDC2, with the ability to bind BV677278. Taken together, these data suggest a possible mechanism by which BV677278 polymorphisms alter PEA3 binding and DCDC2 expression, which in turn may modulate neuronal migration and affect the risk of dyslexia

Optical Rogue Waves in Vortex Turbulence

We present a spatio-temporal mechanism for producing 2D optical rogue waves in the presence of a turbulent state with creation, interaction and annihilation of optical vortices. Spatially periodic structures with bound phase lose stability to phase unbound turbulent states in complex Ginzburg- Landau and Swift-Hohenberg models with external driving. When the pumping is high and the external driving is low, synchronized oscillations are unstable and lead to spatio-temporal turbulence with high excursions in amplitude. Nonlinear amplification leads to rogue waves close to turbulent optical vortices, where the amplitude tends to zero, and to probability distribution functions with long tails typical of extreme optical events.Comment: 5 pages, 7 figure

Applications of percolation theory to fungal spread with synergy

There is increasing interest in the use of the percolation paradigm to analyze and predict the progress of disease spreading in spatially-structured populations of animals and plants. The wider utility of the approach has been limited, however, by several restrictive assumptions, foremost of which is a strict requirement for simple nearest-neighbour transmission, in which the disease history of an individual is in uenced only by that of its neighbours. In a recent paper the percolation paradigm has been generalised to incorporate synergistic interactions in host infectivity and susceptibility and the impact of these interactions on the invasive dynamics of an epidemic has been demonstrated. In the current paper we elicit evidence that such synergistic interactions may underlie transmission dynamics in real-world systems by rst formulating a model for the spread of a ubiquitous parasitic and saprotrophic fungus through replicated populations of nutrient sites and subsequently tting and testing the model using data from experimental microcosms. Using Bayesian computational methods for model tting, we demonstrate that synergistic interactions are necessary to explain the dynamics observed in the replicate experiments. The broader implications of this work in identifying disease control strategies that de ect epidemics from invasive to non-invasive regimes are discussed

A ground-based NUV secondary eclipse observation of KELT-9b

KELT-9b is a recently discovered exoplanet with a 1.49 d orbit around a B9.5/A0-type star. The unparalleled levels of UV irradiation it receives from its host star put KELT-9b in its own unique class of ultra-hot Jupiters, with an equilibrium temperature > 4000 K. The high quantities of dissociated hydrogen and atomic metals present in the dayside atmosphere of KELT-9b bear more resemblance to a K-type star than a gas giant. We present a single observation of KELT-9b during its secondary eclipse, taken with the Wide Field Camera on the Isaac Newton Telescope (INT). This observation was taken in the U-band, a window particularly sensitive to Rayleigh scattering. We do not detect a secondary eclipse signal, but our 3$\sigma$ upper limit of 181 ppm on the depth allows us to constrain the dayside temperature of KELT-9b at pressures of ~30 mbar to 4995 K (3$\sigma$). Although we can place an observational constraint of $A_g<$ 0.14, our models suggest that the actual value is considerably lower than this due to H$^-$ opacity. This places KELT-9b squarely in the albedo regime populated by its cooler cousins, almost all of which reflect very small components of the light incident on their daysides. This work demonstrates the ability of ground-based 2m-class telescopes like the INT to perform secondary eclipse studies in the NUV, which have previously only been conducted from space-based facilities.Comment: Accepted in ApJL. 7 pages, 3 figure

Protein Modularity of Alternatively Spliced Exons Is Associated with Tissue-Specific Regulation of Alternative Splicing

Recent comparative genomic analysis of alternative splicing has shown that protein modularity is an important criterion for functional alternative splicing events. Exons that are alternatively spliced in multiple organisms are much more likely to be an exact multiple of 3 nt in length, representing a class of “modular” exons that can be inserted or removed from the transcripts without affecting the rest of the protein. To understand the precise roles of these modular exons, in this paper we have analyzed microarray data for 3,126 alternatively spliced exons across ten mouse tissues generated by Pan and coworkers. We show that modular exons are strongly associated with tissue-specific regulation of alternative splicing. Exons that are alternatively spliced at uniformly high transcript inclusion levels or uniformly low levels show no preference for protein modularity. In contrast, alternatively spliced exons with dramatic changes of inclusion levels across mouse tissues (referred to as “tissue-switched” exons) are both strikingly biased to be modular and are strongly conserved between human and mouse. The analysis of different subsets of tissue-switched exons shows that the increased protein modularity cannot be explained by the overall exon inclusion level, but is specifically associated with tissue-switched alternative splicing

Dynamics of CrO3–Fe2O3 catalysts during the high-temperature water-gas shift reaction: molecular structures and reactivity

A series of supported CrO3/Fe2O3 catalysts were investigated for the high-temperature water-gas shift (WGS) and reverse-WGS reactions and extensively characterized using in situ and operando IR, Raman, and XAS spectroscopy during the high-temperature WGS/RWGS reactions. The in situ spectroscopy examinations reveal that the initial oxidized catalysts contain surface dioxo (O═)2Cr6+O2 species and a bulk Fe2O3 phase containing some Cr3+ substituted into the iron oxide bulk lattice. Operando spectroscopy studies during the high-temperature WGS/RWGS reactions show that the catalyst transforms during the reaction. The crystalline Fe2O3 bulk phase becomes Fe3O4 ,and surface dioxo (O═)2Cr6+O2 species are reduced and mostly dissolve into the iron oxide bulk lattice. Consequently, the chromium–iron oxide catalyst surface is dominated by FeOx sites, but some minor reduced surface chromia sites are also retained. The Fe3–-xCrxO4 solid solution stabilizes the iron oxide phase from reducing to metallic Fe0 and imparts an enhanced surface area to the catalyst. Isotopic exchange studies with C16O2/H2 → C18O2/H2 isotopic switch directly show that the RWGS reaction proceeds via the redox mechanism and only O* sites from the surface region of the chromium–iron oxide catalysts are involved in the RWGS reaction. The number of redox O* sites was quantitatively determined with the isotope exchange measurements under appropriate WGS conditions and demonstrated that previous methods have undercounted the number of sites by nearly 1 order of magnitude. The TOF values suggest that only the redox O* sites affiliated with iron oxide are catalytic active sites for WGS/RWGS, though a carbonate oxygen exchange mechanism was demonstrated to exist, and that chromia is only a textural promoter that increases the number of catalytic active sites without any chemical promotion effect

Signatures of hybridization in <i>Trypanosoma brucei</i>

Genetic exchange among disease-causing micro-organisms can generate progeny that combine different pathogenic traits. Though sexual reproduction has been described in trypanosomes, its impact on the epidemiology of Human African Trypanosomiasis (HAT) remains controversial. However, human infective and non-human infective strains of Trypanosoma brucei circulate in the same transmission cycles in HAT endemic areas in subsaharan Africa, providing the opportunity for mating during the developmental cycle in the tsetse fly vector. Here we investigated inheritance among progeny from a laboratory cross of T. brucei and then applied these insights to genomic analysis of field-collected isolates to identify signatures of past genetic exchange. Genomes of two parental and four hybrid progeny clones with a range of DNA contents were assembled and analysed by k-mer and single nucleotide polymorphism (SNP) frequencies to determine heterozygosity and chromosomal inheritance. Variant surface glycoprotein (VSG) genes and kinetoplast (mitochondrial) DNA maxi- and minicircles were extracted from each genome to examine how each of these components was inherited in the hybrid progeny. The same bioinformatic approaches were applied to an additional 37 genomes representing the diversity of T. brucei in subsaharan Africa and T. evansi. SNP analysis provided evidence of crossover events affecting all 11 pairs of megabase chromosomes and demonstrated that polyploid hybrids were formed post-meiotically and not by fusion of the parental diploid cells. VSGs and kinetoplast DNA minicircles were inherited biparentally, with approximately equal numbers from each parent, whereas maxicircles were inherited uniparentally. Extrapolation of these findings to field isolates allowed us to distinguish clonal descent from hybridization by comparing maxicircle genotype to VSG and minicircle repertoires. Discordance between maxicircle genotype and VSG and minicircle repertoires indicated inter-lineage hybridization. Significantly, some of the hybridization events we identified involved human infective and non-human infective trypanosomes circulating in the same geographic areas